Transplantation of a Beating Heart: A First in Human

• 作者： Yin Shengli ¹ Rong Jian ² Chen Yinghua ^3,4,5 Cao Lu ² Liu Yunqi ¹ Mo Shaoyan ² Li Hanzhao ¹ Jiang Nan ⁶ Xiong Mai ¹ Shi Han ² Wang Tielong ^3,4,5 Shi Yongxu ² Zhu Yanlin ² Liang Mengya ¹ Xiong Wei ⁶ Chen Yili ⁷ Xu Guixing ⁸ Chen Xiaoxiang ⁶ Chen Xiaojun ⁹ Yin Meixian ^3,4,5 Tang Baiyun ¹⁰ Gong Fengqiu ⁹ Huang Wenqi ⁶ Dong Yugang ⁷ Bj?rn Nashan ¹¹ Stefan G Tullius ¹² Guo Zhiyong ^3,4,5 Wu Zhongkai ¹ He Xiaoshun ^3,4,5
• 作者单位：
  1.  Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University,

  2.  Department of Extracorporeal Circulation, The First Affiliated Hospital, Sun Yat-sen University

  3.  Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University

  4.  Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation)

  5.  Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology

  6.  Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University

  7.  Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University

  8.  Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University

  9.  Operating Room and Anesthesia Center, The First Affiliated Hospital, Sun Yat-sen University

  10.  Cardiac Surgery Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University

  11.  Organ Transplantation Center, The First Affiliated Hospital of the University of Science and Technology of China

  12.  Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School
• 提交时间：2021-10-02

摘要 ： Ischemia and reperfusion injury (IRI), an inevitable component in organ transplantation, contributes to inferior graft survival, compromised organ quality and limitations in organ availability. The heart is most vulnerable to IRI and tolerated ischemic times are very short. We present an entire novel heart transplant procedure during which the donor heart was continuously perfused, oxygenated at normothermia and transplanted while beating. The dynamic electrocardiogram and echocardiogram indicated an absence of ischemic injury and excellent function of the donor heart during the entire procedure. This ischemia-free beating heart transplantation (IFBHT) avoids graft IRI. The approach has thus the potential to improve transplant outcome while improving organ utilization.

• 来自： 尹美娴
• 分类： 医学、药学 >> 临床医学
• 引用： ChinaXiv:202110.00002 (或此版本 ChinaXiv:202110.00002V1)
  doi:10.12074/202110.00002
  CSTR:32003.36.ChinaXiv.202110.00002.V1
• 推荐引用方式： Yin Shengli,Rong Jian,Chen Yinghua,Cao Lu,Liu Yunqi,Mo Shaoyan,Li Hanzhao,Jiang Nan,Xiong Mai,Shi Han,Wang Tielong,Shi Yongxu,Zhu Yanlin,Liang Mengya,Xiong Wei,Chen Yili,Xu Guixing,Chen Xiaoxiang,Chen Xiaojun,Yin Meixian,Tang Baiyun,Gong Fengqiu,Huang Wenqi,Dong Yugang,Bj?rn Nashan,Stefan G Tullius,Guo Zhiyong,Wu Zhongkai,He Xiaoshun.(2021).Transplantation of a Beating Heart: A First in Human.CSTR:32003.36.ChinaXiv.202110.00002.V1 (点此复制)