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Transplantation of a Beating Heart: A First in Human

Submit Time: 2021-10-02
Author: Yin Shengli 1 ; Rong Jian 2 ; Chen Yinghua 3,4,5 ; Cao Lu 2 ; Liu Yunqi 1 ; Mo Shaoyan 2 ; Li Hanzhao 1 ; Jiang Nan 6 ; Xiong Mai 1 ; Shi Han 2 ; Wang Tielong 3,4,5 ; Shi Yongxu 2 ; Zhu Yanlin 2 ; Liang Mengya 1 ; Xiong Wei 6 ; Chen Yili 7 ; Xu Guixing 8 ; Chen Xiaoxiang 6 ; Chen Xiaojun 9 ; Yin Meixian 3,4,5 ; Tang Baiyun 10 ; Gong Fengqiu 9 ; Huang Wenqi 6 ; Dong Yugang 7 ; Bj?rn Nashan 11 ; Stefan G Tullius 12 ; Guo Zhiyong 3,4,5 ; Wu Zhongkai 1 ; He Xiaoshun 3,4,5 ;
Institute: 1.Department of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University,; 2.Department of Extracorporeal Circulation, The First Affiliated Hospital, Sun Yat-sen University; 3.Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University; 4.Guangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation); 5.Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology; 6.Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University; 7.Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University; 8.Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University; 9.Operating Room and Anesthesia Center, The First Affiliated Hospital, Sun Yat-sen University; 10.Cardiac Surgery Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University; 11.Organ Transplantation Center, The First Affiliated Hospital of the University of Science and Technology of China; 12.Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School;

Abstracts

Ischemia and reperfusion injury (IRI), an inevitable component in organ transplantation, contributes to inferior graft survival, compromised organ quality and limitations in organ availability. The heart is most vulnerable to IRI and tolerated ischemic times are very short. We present an entire novel heart transplant procedure during which the donor heart was continuously perfused, oxygenated at normothermia and transplanted while beating. The dynamic electrocardiogram and echocardiogram indicated an absence of ischemic injury and excellent function of the donor heart during the entire procedure. This ischemia-free beating heart transplantation (IFBHT) avoids graft IRI. The approach has thus the potential to improve transplant outcome while improving organ utilization.
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From: 尹美娴
DOI:10.12074/202110.00002
Recommended references: Yin Shengli,Rong Jian,Chen Yinghua,Cao Lu,Liu Yunqi,Mo Shaoyan,Li Hanzhao,Jiang Nan,Xiong Mai,Shi Han,Wang Tielong,Shi Yongxu,Zhu Yanlin,Liang Mengya,Xiong Wei,Chen Yili,Xu Guixing,Chen Xiaoxiang,Chen Xiaojun,Yin Meixian,Tang Baiyun,Gong Fengqiu,Huang Wenqi,Dong Yugang,Bj?rn Nashan,Stefan G Tullius,Guo Zhiyong,Wu Zhongkai,He Xiaoshun.(2021).Transplantation of a Beating Heart: A First in Human.[ChinaXiv:202110.00002] (Click&Copy)
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[V1] 2021-10-02 17:08:01 chinaXiv:202110.00002V1 Download
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