Current Location:home > Detailed Browse

Article Detail

Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype

Abstracts

Tumor resistance is a major hurdle to anti-Her2/neu Ab-based cancer therapy. Current strategies to overcome tumor resistance focus on tumor cell-intrinsic resistance. However, the extrinsic mechanisms, especially the tumor microenvironment, also play important roles in modulating the therapeutic response and resistance of the Ab. In this study, we demonstrate that tumor progression is highly associated with TAMs with immune-suppressive M2 phenotypes, and deletion of TAMs markedly enhanced the therapeutic effects of anti-Her2/neu Ab in a HER2/neu-dependent breast cancer cell TUBO model. Tumor local delivery of IL-21 can skew TAM polarization away from the M2 phenotype to a tumor-inhibiting M1 phenotype, which rapidly stimulates T cell responses against tumor and dramatically promotes the therapeutic effect of anti-Her2 Ab. Skewing of TAM polarization by IL-21 relies substantially on direct action of IL-21 on TAMs rather than stimulation of T and NK cells. Thus, our findings identify the abundant TAMs as a major extrinsic barrier for anti-Her2/neu Ab therapy and present a novel approach to combat this extrinsic resistance by tumor local delivery of IL-21 to skew TAM polarization. This study offers a therapeutic strategy to modulate the tumor microenvironment to overcome tumor-extrinsic resistance.
Download Comment Hits:1070 Downloads:517
Journal:JOURNAL OF IMMUNOLOGY
Recommended references: Xu, Meng,Liu, Mingyue,Du, Xuexiang,Li, Sirui,Li, Hang,Li, Xiaozhu,Li, Ying,Qin, Zhihai,Fu, Yang-Xin,Wang, Shengdian,Xu, Meng,Liu, Mingyue,Du, Xuexiang,Li, Sirui,Wang, Yang,Fu, Yang-Xin.(2016).Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype.JOURNAL OF IMMUNOLOGY.[ChinaXiv:201605.01515] (Click&Copy)
Version History
[V1] 2016-05-12 08:40:41 chinaXiv:201605.01515V1 Download
Related Paper

Download

Current Browse

Change Subject Browse

Cross Subject Browse

  • - NO